Bernardshaw S, HetlandG, Ellertsen LK, Tryggestad AM, Johnson E: An extract of the medicinal mushroom Agaricus blazei Murilldifferentially stimulates production of pro-inflammatory cytokines in humanmonocytes and human vein endothelial cells in vitro. Inflammation. 2005 Dec;29(4-6):147-53.
Choi YH, Yan GH, Chai OH, Choi YH, Zhang X,Lim JM, Kim JH, Lee MS, Han EH, Kim HT, Song CH: Inhibitory effects of Agaricusblazei on mast cell-mediated anaphylaxis-like reactions. Biol Pharm Bull. 2006 ju1;29(7):1366-71.
Hsu CH, Liao YL, Lin SC,Hwang KC, Chou P: The mushroom Agaricus Blazei Murill in combination with metformin and gliclazideimproves insulin resistance in type 2 diabetes: a randomized, doubleblinded, and placebo-controlled clinical trial. JAltern Complement Med. 2007 Jan-Feb;13(1):97-102.
Katakura R: Selectivetumoricidal effect of soluble proteoglucan extracted from the basidiomycete,Agaricus blazei Murill, mediated via natural killer cell activation andapoptosis. Cancer Immunol Immunother. 1998 May;46(3):147-59
Kimura Y, Kido T, TakakuT, Sumiyoshi M, Baba K: Isolation of an anti angiogenic substance from Agaricus blazeiMurill: its antitumor and antimetastatic actions. Cancer Sci. 2004Sep;95(9):758-64.
Kobayashi H, Yoshida R, Kanada Y, Fukuda Y, Yagyu T, InagakiK, Kondo T, Kurita N, Suzuki M, Kanayama N,Terao T: Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill onspontaneous and peritoneal disseminated metastasis in mouse model. J Cancer Res Clin Oncol. 2005Aug;131(8):527-38.
Yuminamochi E, Koike T, Takeda K, Horiuchi I,Okumura K: Interleukin-12- and interferongammamediated natural killer cell activation byAgaricus blazei Murill. Immunology. 2007 Jun;121(2):197-206
Quelle MRC Austria
1) Suppressing effects of daily oral supplementation of beta-glucan extracted
from Agaricus blazei Murill on spontaneous and peritoneal disseminated metas-tasis in mouse model. Kobayashi H, Yoshida R, Kanada Y, Fukuda Y, Yagyu T, Ina-
gaki K, Kondo T, Kurita N, Suzuki M, Kanayama N, Terao T. J Cancer Res Clin Oncol.2005;131(8):527-38.
2) Effects of Agaricus brasiliensis mushroom in Walker-256 tumor-bearing rats. Ju-mes F.M, Lugarini D, Pereira A.L, de Oliveira A, Christoff Ade O, Linde G.A, do Valle J.S,Colauto N.B, Acco A. Can J Physiol Pharmacol. 2010;88(1):21-7.
3) Inhibitory mechanisms of Agaricus blazei Murill on the growth of prostate cancerin vitro and in vivo. Yu C.H, Kan S.F, Shu C.H, Lu T.J, Sun-Hwang L, Wang P.S. J NutrBiochem. 2009;20(10):753-64.
4) Immunomodulating activity of Agaricus brasiliensis KA21 in mice and in hu-
man volunteers. Liu Y, Fukuwatari Y, Okumura K, Takeda K, Ishibashi KI, Furuka-
wa M, Ohno N, Mori K, Gao M, Motoi M. Evid Based Complement Alternat Med.2008;5(2):205-219.
5) Natural killer cell activity and quality of life were improved by consumption of amushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patientsundergoing chemotherapy. Ahn W.S, et al. Int J Gynecol Cancer 2004;14(4):589-594.
6) Clinical observation on treatment of acute non lymphocytic leukemia with Agari-cus blazei. X. Tian, Z. Lun and H. Ito. J. Lanzhou Med. Coll. 20 (1994), pp. 169–171
7) Observation on treatment effect of Agaricus blazei against alimentary tract tumor.Wang J., Mou X.M. and Cheng R.Z. Gansu Med J. 1994;13:5–7
8) White button mushroom phytochemicals inhibit aromatase activity and breastcancer cell proliferation. Grube B.J, Eng E.T, Kao Y.C, Kwon A, Chen S. J Nutr.2001;131(12):3288-93.
9) Anti-aromatase activity of phytochemicals in white button mushrooms (Agaricusbisporus). Chen S, Oh S.R, Phung S, Hur G, Ye J.J, Kwok S.L, Shrode G.E, Belury M,Adams L.S, Williams D. Cancer Res. 2006;66(24):12026-34.
10) Medicinal properties and clinical effects of culinary-medicinal mushroomAgaricus blazei Murrill (Agaricomycetideae) (Review). Mizuno T. Int J Med Mushr2002;4:299–312.
11) Agaricus blazei (Himematsutake) does not alter the development of rat diethyl-nitrosamine-initiated hepatic preneoplastic foci. Barbisan L.F, Spinardi-Barbisan
A.L, Moreira E.L, Salvadori D.M, Ribeiro L.R, da Eira A.F, de Camargo J.L. Cancer Sci.2003;94(2):188-92.
12) Screening for in vitro and in vivo antitumor activities of the mushroom Agaricusblazei. Ziliotto L, Pinheiro F, Barbisan L.F, Rodrigues M.A. Nutr Cancer. 2009;61(2):245-50
13) Variation of the antimutagenicity effects of water extracts of Agaricus blazei Mur-rill in vitro. Guterrez Z.R, Mantovani M.S, Eira A.F, Ribeiro L.R, Jordão B.Q. Toxicol InVitro. 2004;18(3):301-9
14) Effects of the medicinal mushroom Agaricus blazei Murill on immunity, infectionand cancer. Hetland G, Johnson E, Lyberg T, Bernardshaw S, Tryggestad A.M, GrindeB. Scand J Immunol. 2008;68(4):363-70
15) An extract of the medicinal mushroom Agaricus blazei Murill can protect againstallergy. Ellertsen L.K, Hetland G. Clin Mol Allergy. 2009:5;7-6.
16) The mushroom Agaricus blazei Murill extract normalizes liver function in patientswith chronic hepatitis B. Hsu C.H, Hwang K.C, Chiang Y.H, Chou P. J Altern Comple-ment Med. 2008;14(3):299-301
17) Clinical utility of ABCL (Agaricus Mushroom Extract) treatment for C-type hepati-tis. Jpn Pharmacol Ther. 2002;30:103-7
18) Observation on the treatment effect of Agaricus blazei to the liver function ofchronic hepatitis patients. Wang L. and Ma H. J Lanzhou Med Coll. 2004;20:24–26
19) An alternative medicine, Agaricus blazei, may have induced severe hepatic dys-function in cancer patients. Mukai H, Watanabe T, Ando M, Katsumata N. Jpn J ClinOncol. 2006 Dec;36(12):808-10.
20) Hetland G, Johnson E, Lyberg T, Bernardshaw S, Tryggestad AM, Grinde B (2008).„Effects of the medicinal mushroom Agaricus blazei Murill on immunity, infectionand cancer“. Scand J Immunol 68 (4): 363–70. doi:10.1111/j.1365-3083.2008.02156.x.PMID 18782264.
21) Bernardshaw S, Lyberg T, Hetland G, Johnson E: Effect of an extract of the mus-hroom Agaricus blazei Murill on expression of adhesion molecules and production
of reactive oxygen species in monocytes and granulocytes in human whole blood exvivo. APMIS. 2007 Jun;115(6):719-25.
22) Bernardshaw S, Hetland G, Ellertsen LK, Tryggestad AM, Johnson E: An extract ofthe medicinal mushroom Agaricus blazei Murill differentially stimulates productionof pro-inflammatory cytokines in human monocytes and human vein endothelialcells in vitro.
Inflammation. 2005 Dec;29(4-6):147-53
23) Hsu CH, Liao YL, Lin SC, Hwang KC, Chou P: The mushroom Agaricus Blazei Murillin combination with metformin and gliclazide improves insulin resistance in type 2diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Al-tern Complement Med. 2007 Jan-Feb;13(1):97-102
24) Chan Y, Chang T, Chan CH, Yeh YC, Chen CW, Shieh B, Li C: Immunomodulatoryeffects of Agaricus blazei Murill in Balb/cByJ mice. J Microbiol Immunol Infect. 2007Jun;40(3):201-8
25) Choi YH, Yan GH, Chai OH, Choi YH, Zhang X, Lim JM, Kim JH, Lee MS, Han EH,Kim HT, Song CH: Inhibitory effects of Agaricus blazei on mast cell-mediated ana-phylaxis-like reactions. Biol Pharm Bull. 2006 Jul;29(7):1366-71.
Bao XF, Wang XS, Dong 0, Fang JN, Li XY :Structural features of immunologically active polysaccharides from Ganoderma lucidum.Phytochemistry. 2002 Jan;59(2):175-81.
Bao XF, Wang XS, Dong Q, Fang JN, Li XY :Structural features of immunologically active polysaccharides from Ganoderma lucidum.Phytochemistry. 2002 Jan:59(2):175-81.
Gao Y, Zhou S, bang W,Huang M, Dai X: Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on theimmune functions in advanced stage cancer patients. Immunol Invest. 2003 Aug;32(3):201-15.
Hajjaj H, Mace C,Roberts M, Niederberger P, Fay LB: Effect of 26-oxygenosterols from Ganoderma lucidum and theiractivity as cholesterol synthesis inhibitors. Appl Environ Microbiol. 2005 Jul;71(7):3653-8.
Hua KF, Hsu HY, Chao LK,Chen ST, Yang WB, Hsu J, Wong CH: Ganoderma lucidum polysaccharides enhance CD14endocytosis of LPS and promote TLR4 signal transduction of cytokine expression. J CellPhysiol. 2007;212(2):537-50.
Ji Z, Tang 0, Zhang J, Yang Y, Jia W, Pan Y:Immunomodulation of RAW264.7 macrophages by GLIS, a proteopolysaccharide from Ganoderma lucidum. J Ethnopharmacol.2007;112(3):445-50.
Kuo MC, Weng CY, Ha CL, Wu MJ :Ganoderma lucidummycelia enhance innate immunity by activating NFkappaB. J Ethnopharmacol. 2006 Jan 16;103(2):217-22.
Liu J, Shimizu K,Konishi F, Kumamoto S, Kondo R: The antiandrogen effect of ganoderol B isolatedfrom the fruiting bodyof Ganoderma lucidum. Bioorg Med Chem. 2007 Jul 15;15(14):4966-72.
Wachtel-Galor S,Tomlinson B, Benzie IF: Ganoderma lucidum („Lingzhi"), a Chinese medicinalmushroom: biomarkerresponses in a controlled human supplementation study. Br J Nutr. 2004 Feb;91(2):263-9.
Xi Bao Y, Kwok Wong C,Kwok Ming Li E, Shan Tam L, Chung Leung P, Bing Yin Y, Wai Kei Lam C: Immunomodulatoryeffects of lingzhi and san-miao-san supplementation on patients with rheumatoid arthritis.Immunopharmacol Immunotoxicol. 2006;28(2):197-200.
Quelle MRC Austria
1) Anticancer effects ofGanoderma lucidum: a review of scientific evidence. Yuen J.W, Gohel M.D. NutrCancer. 2005;53(1):11-7.
2) Regression of gastriclarge B-Cell lymphoma accompanied by a florid lymphoma-like T-cell reaction:immunomodulatory effect of Ganoderma lucidum (Lingzhi)? Cheuk W, Chan J.K,Nuovo G, Chan M.K, Fok M. Int J Surg Pathol. 2007;15(2):180-6.
3) Potential of a novelpolysaccharide preparation (GLPP) from Anhui-grown Ganoderma lucidum in tumortreatment and immunostimulation. Pang X, Chen Z, Gao X, Liu W, Slavin M, Yao W,Yu L.L. J Food Sci. 2007;72(6):S435-42.
4) Cytotoxic triterpenoidsfrom Ganoderma lucidum. Cheng C.R, Yue Q.X, Wu Z.Y, Song X.Y, Tao S.J, Wu X.H,Xu P.P, Liu X, Guan S.H, Guo D.A. Phytochemistry. 2010;71(13):1579-1585.
5) Triterpenes fromGanoderma lucidum induce autophagy in colon cancer through the inhibition ofp38 mitogen-activated kinase (p38 MAPK). Thyagarajan A, Jedinak A, Nguyen H,Terry C, Baldridge L.A, Jiang J, Sliva D. Nutr Cancer. 2010;62(5):630-40.
6) Ganoderic acid Tinhibits tumor invasion in vitro and in vivo through inhibition of MMPexpression. Chen N.H, Liu J.W, Zhong J.J. Pharmacol Rep. 2010;62(1):150-63.
7) Inhibitory effects ofganoderma lucidum on tumorigenesis and metastasis of human hepatoma cells incells and animal models. Weng C.J, Chau C.F, Yen G.C, Liao J.W, Chen D.H, ChenK.D. J Agric Food Chem. 2009;57(11):5049-57.
8) Cytotoxic lanostanoidtriterpenes from Ganoderma lucidum. Guan S.H, Xia J.M, Yang M, Wang X.M, Liu X,Guo D.A. J Asian Nat Prod Res. 2008;10(7-8):705-10.
9) The anti-invasiveeffect of lucidenic acids isolated from a new Ganoderma lucidum strain. WengC.J, Chau C.F, Chen K.D, Chen D.H, Yen G.C. Mol Nutr Food Res. 2007;51(12):1472-7.
10) Lucidenic acids P andQ, methyl lucidenate P, and other triterpenoids from the fungus Ganodermalucidum and their inhibitory effects on Epstein-Barr virus activation. IwatsukiK, Akihisa T, Tokuda H, Ukiya M, Oshikubo M, Kimura Y, Asano T, Nomura A,Nishino H.J Nat Prod. 2003 Dec;66(12):1582-5.
11) Suppression of theinflammatory response by triterpenes isolated from the mushroom Ganodermalucidum. Dudhgaonkar S, Thyagarajan A, Sliva D.Int Immunopharmacol.2009;9(11):1272-80.
12) Ganoderma lucidumsuppresses motility of highly invasive breast and prostate cancer cells. SlivaD, Labarrere C, Slivova V, Sedlak M, Lloyd F.P Jr, Ho N.W. Biochem Biophys ResCommun. 2002;298(4):603-12.
13) Ganoderma lucidumsuppresses growth of breast cancer cells through the inhibition ofAkt/NF-kappaB signaling. Jiang J, Slivova V, Harvey K, Valachovicova T, SlivaD. Nutr Cancer. 2004;49(2):209-16.
14) Effects of ganopoly (aGanoderma lucidum polysaccharide extract) on the immune functions inadvanced-stage cancer patients. Gao Y, Zhou S, Jiang W, Huang M, Dai X. ImmunolInvest. 2003;32(3):201-15.
15) Effects ofwater-soluble Ganoderma lucidum polysaccharides on the immune functions ofpatients with advanced lung cancer. Gao Y, Tang W, Dai X, Gao H, Chen G, Ye J, ChanE, Koh H.L, Li X, Zhou S. J Med Food. 2005;8(2):159-68.
16) Anti-allergicconstituents in the culture medium of Ganoderma lucidum. (I). Inhibitory effectof oleic acid on histamine release. Tasaka K, Akagi M, Miyoshi K, Mio M, MakinoT. Inflammation Research. 1988;23(3-4):153-6
17) Anti-allergicconstituents in the culture medium of Ganoderma lucidum. (II). The inhibitoryeffect of cyclooctasulfur on histamine release. Tasaka K, Mio M, Izushi K,Akagi M, Makino T. Inflammation Research. 1988;23(3-4):157-60.
18) Effectiveness of Dp2nasal therapy for Dp2- induced airway inflammation in mice: using oralGanoderma lucidum as an immunomodulator. Liu Y.H, Tsai C.F, Kao M.C, Lai Y.L,Tsai J.J. J Microbiol Immunol Infect. 2003;36(4):236-428.
19) The use of Ganodermalucidum (Reishi) in the management of Histamine-mediated allergic responses.Powell M. Nutritional Practitioner Magazine. October 2004
20) The Chinese herbalmedicine formula FAHF-2 completely blocks anaphylactic reactions in murinemodel of peanut allergy. Srivastava K.D, Kattan J.D, Zou Z.M, Li J.H, Zhang L,Wallenstein S, Goldfarb J, Sampson H.A, Li X.M. J Allergy Clin Immunol.2005;115(1):171-8.
21) Antimutagenic activityof methanolic extract of Ganoderma lucidum and its effect on hepatic damagecaused by benzo[a]pyrene. Lakshmi B, Ajith T.A, Jose N, Janardhanan K.K. JEthnopharmacol. 2006;107(2):297-303.
22) Effects of Ganodermalucidum polysaccharide on CYP2E1, CYP1A2 and CYP3A activities in BCG-immunehepatic injury in rats. Wang X, Zhao X, Li D, Lou Y.Q, Lin Z.B, Zhang G.L. BiolPharm Bull. 2007;30(9):1702-6.
23) Post-treatment ofGanoderma lucidum reduced liver fibrosis induced by thioacetamide in mice. WuY.W, Fang H.L, Lin W.C. Phytother Res. 2010;24(4):494-9.
24) In vitro and in vivo protectiveeffects of proteoglycan isolated from mycelia of Ganoderma lucidum on carbontetrachloride-induced liver injury. Yang X.J, Liu J, Ye L.B, Yang F, Ye L, GaoJ.R, Wu Z.H. World J Gastroenterol. 2006;12(9):1379-85.
25) Antifibrotic effectsof a polysaccharide extracted from Ganoderma lucidum, glycyrrhizin, andpentoxifylline in rats with cirrhosis induced by biliary obstruction. Park E.J,Ko G, Kim J, Sohn D.H. Biol Pharm Bull. 1997;20(4):417-20.
26) Ganoderma lucidumextract attenuates the proliferation of hepatic stellate cells by blocking thePDGF receptor. Wang G.J, Huang Y.J, Chen D.H, Lin Y.L. Phytother Res.2009;23(6):833-9.
27) Treatment of chronichepatitis B with Wulingdan Pill. Journal of the fourth Military MedicalCollege. 8:380-383. From Abstracts of Chinese Medicines 2:188
28) Effects of totalTriterpenoids extract from Ganoderma lucidum (Curt.: Fr.) P. Karst. (ReishiMushroom) on experimental liver injury models induced by Carbon Tetrachlorideor D-Galactosamine in mice. Lin Z.B, Wang M.Y, Liu Q, Che Q.M. Int J Med Mushr.2002;4(1):37-41
29) Anti-hepatitis Bactivities of ganoderic acid from Ganoderma lucidum. Li Y.Q, Wang S.F.Biotechnol Lett. 2006;28(11):837-41.
30) A phase I/II study ofling zhi mushroom Ganoderma lucidum (W.Curt.:Fr.) Lloyd(Aphyllophoromycetideae) extract in patients with coronary heart disease. GaoY, Chen G, Dai X, Ye J, Zhou S. Int J Med Mushr. 2004;6(4):30
31) Effect of Ganodermalucidum on the quality and functionality of Korean traditional rice wine,yakju. Kim J.H, Lee D.H, Lee S.H, Choi S.Y, Lee J.S. J Biosci Bioeng.2004;97(1):24-8.
32) A preliminary study onthe sleep-improvement function of the effective ingredients of Ganodermalucidum fruitbody. Jia W, Wu M, Zhang J.S, Liu Y.F. Acta Edulis Fungi. 2005;12(3):43-47
33) Sleep-promotingeffects of Ganoderma extracts in rats: comparison between long-term and acuteadministrations. Honda K, Komoda Y, Inoué S. Tokyo Ika Shika Daigaku Iyo KizaiKenkyusho Hokoku. 1988;22:77-82.
34) Extract of Ganodermalucidum potentiates pentobarbital-induced sleep via a GABAergic mechanis. ChuQ.P, Wang L.E, Cui X.Y, Fu H.Z, Lin Z.B, Lin S.Q, Zhang Y.H. PharmacologyBiochemistry and Behavior 2007;86(4):693-698
35) Ganoderma lucidumpolysaccharide peptide reduced the production of proinflammatory cytokines inactivated rheumatoid synovial fibroblast. Ho Y.W, Yeung J.S, Chiu P.K, TangW.M, Lin Z.B, Man R.Y, Lau C.S. Mol Cell Biochem. 2007;301(1-2):173-9.
36) Antagonizingbeta-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidum.Lai C.S, Yu M.S, Yuen W.H, So K.F, Zee S.Y, Chang R.C. Brain Res.2008;1190:215-24.
37) Novel hypoglycemiceffects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice.Seto S.W, Lam T.Y, Tam H.L, Au A.L, Chan S.W, Wu J.H, Yu P.H, Leung G.P, NgaiS.M, Yeung J.H, Leung P.S, Lee S.M, Kwan Y.W. Phytomedicine. 2009;16(5):426-36.
38) Cholesterol-loweringproperties of Ganoderma lucidum in vitro, ex vivo, and in hamsters andminipigs. Berger A, Rein D, Kratky E, Monnard I, Hajjaj H, Meirim I,Piguet-Welsch C, Hauser J, Mace K, Niederberger P. Lipids Health Dis. 2004;3:2.
39) Ganoderic acid and itsderivatives as cholesterol synthesis inhibitors. Komoda Y, Shimizu M, Sonoda Y,Sato Y. Chem Pharm Bull (Tokyo). 1989;37(2):531-3.
40) Anti-atheroscleroticproperties of higher mushrooms (a clinico-experimental investigation). Li K.R,Vasil’ev A.V, Orekhov A.N, Tertov V.V, Tutel’ian V.A. Vopr Pitan.1989;(1):16-9.
41) Bao XF, Wang XS, DongQ, Fang JN, Li XY : Structural features of immunologically activepolysaccharides from Ganoderma lucidum Lexikon. Phytochemistry. 2002Jan;59(2):175-81
42) Zhang J, Tang Q,Zimmerman-Kordmann M, Reutter W, Fan H: Activation of B lymphocytes by GLIS, abioactive proteoglycan from Ganoderma lucidum Lexikon. Life Sci. 2002 Jun28;71(6):623-38.
43) Ji Z, Tang Q, Zhang J,Yang Y, Jia W, Pan Y: Immunomodulation of RAW264.7 macrophages by GLIS, aproteopolysaccharide from Ganoderma lucidum Lexikon. J Ethnopharmacol.2007;112(3):445-50.
44) Hua KF, Hsu HY, Chao LK,Chen ST, Yang WB, Hsu J, Wong CH: Ganoderma lucidum Lexikon polysaccharidesenhance CD14 endocytosis of LPS and promote TLR4 signal transduction ofcytokine expression. J Cell Physiol. 2007;212(2):537-50.
45) Kuo MC, Weng CY, HaCL, Wu MJ :Ganoderma lucidum mycelia enhance innate immunity by activatingNF-kappaB. J Ethnopharmacol. 2006 Jan 16;103(2):217-22.
46) Li Khva Ren , Vasil'evAV, Orekhov AN, Tertov VV, Tutel'ian VA: Anti-atherosclerotic properties ofhigher mushrooms (a clinico-experimental investigation) Vopr Pitan. 1989Jan-Feb;(1):16-9.
47) Wachtel-Galor S,Tomlinson B, Benzie IF: Ganoderma lucidum Lexikon ("Lingzhi"), aChinese medicinal mushroom: biomarker responses in a controlled humansupplementation study. Br J Nutr. 2004 Feb;91(2):263-9.
Cui FJ, Tao WY, Xu ZH,Guo WJ, Xu HY, Ao ZH, Jin J, Wei YQ: Structural analysis of antitumorheteropolysaccharide GFPS1b from the cultured mycelia of Grifola frondosaGF9801. Bioresour Technol. 2007 Jan;98(2):395-401.
Cui FJ, Li Y, Xu YY, LiuZQ, Huang DM, Zhang ZC, Tao WY: Induction of apoptosis . in SGC7901 cells bypolysaccharidepeptide GFPS1b from the cultured mycelia of Grifola frondosa GF9801. Toxicol InVitro. 2007 Apr;21(3):417-27.
Mayell M: Maitakeextracts and their therapeutic potential. Altern Med Rev. 2001 Feb;6(1):48-60.
Gu CQ, Li J, Chao FH:Inhibition of hepatitis B virus by D-fraction from Grifola frondosa: synergistic effect ofcombination with interferonalpha in HepG2 2.2.15. Antiviral Res. 2006 Nov;72(2):162-5.
Ishibashi K, Miura NN,Adachi Y, Ohno N, Yadomae T.: Relationship between solubility of grifolan, a fungal1,3-beta D-glucan, and production of tumor necrosis factor by macrophages in vitro. BiosciBiotechnol Biochem. 2001 Sep;65(9):1993-2000.
Kodama N, Asakawa A, Inui A, Masuda Y, Nanba H:Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa. Oncol Rep. 2005Mar;13(3):497-502.
Lin JT, Liu WH: o-Orsellinaldehyde from thesubmerged culture of the edible mushroom Grifolafrondosa exhibits selective cytotoxic effect against Hep 3B cells throughapoptosis. J Agric Food Chem. 2006 Oct 4;54(20):7564-9.
Manohar V, Talpur NA,Echard BW, Lieberman S, Preuss HG: Effects of a watersoluble extract of maitake mushroom ancirculating glucose/insulin concentrations in KK mice. Diabetes Obes Metab. 2002 Jan;4(1):43-8.
Quelle MRC Austria
1. A polysaccharideextracted from Grifola frondosa enhances the anti-tumor activity of bonemarrow-derived dendritic cell-based immunotherapy against murine colon cancer.Masuda Y, Ito K, Konishi M, Nanba H. Cancer Immunol Immunother. 2010.
2. Maitake extracts andtheir therapeutic potential – A review. Mayell M. Alt Med Rev, 2001;6(1)
3. Grifola frondosa(Dicks.: Fr.) S.F. Gray (Maitake Mushroom): medicinal properties, activecompounds, and biotechnological cultivation. Boh B, Berovic M.M. Int J MedMushr. 2007;9(2):10.
4. Anti tumor activity oforally administered d-fraction from Maitake (Grifola frondosa). Nanba H. JNaturopathic Medicine. 1993;1:10-15
5. Maitake D-fraction:healing and preventive potential for cancer. Nanba H. J Orthomolecular Med.1997;12:43-49
6. Can Maitake MD-fractionaid cancer patients? Kodama N, Komuta K, Nanba H. Alt Med Rev. 2002;(7)3:236-9
7. Anti-diabetic activitypresent in the fruit body of Grifola frondosa (Maitake). Kubo K, Aoki H, NanbaH. Biol Pharm Bull. 1994;17:1106-1110
8. Anti-diabetic effect ofan alpha-glucan from fruit body of maitake (Grifola frondosa) on KK-Ay mice.Hong L, Xun M, Wutong W. J Pharm Pharmacol. 2007;59(4):575-82.
9. Anticancer andhypoglycemic effects of Polysaccharides in edible and medicinal Maitakemushroom [Grifola frondosa (Dicks.: Fr.) S. F. Gray] Konno S et al. Int J MedMushr 4:3
10. Anti-hyperliposiseffect of Maitake fruit body (Grifola frondosa) Kubo K, Nanba H. Biol PharmBull. 1997;20:781-785
11. Blood pressurelowering activity present in the fruit body of Grifola frondosa (maitake).Adachi K, Nanba H, Otsuka M, Kuroda H. Chen Pharm Bull. 1988;36:1000-1006
12. Effect of shiitake(Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressureand plasma lipids in spontaneously hypertensive rats. Kabir Y, Yamaguchi M,Kimua S. J Nutr Sci Vitaminol. 1987;33:341-346
13. Dietary mushroomsreduce blood pressure in spontaneously hypertensive rats (SHR). Kabir Y, KimuraS. J Nutr Sci Vitaminol. 1989;35:91-94
14) Deng G, Lin H, SeidmanA, et al. (September 2009). "A phase I/II trial of a polysaccharideextract from Grifola frondosa (Maitake mushroom) in breast cancer patients:immunological effects". Journal of Cancer Research and Clinical Oncology135 (9): 1215–21. doi:10.1007/s00432-009-0562-z. PMID 19253021.
15) Kodama N, Komuta K,Nanba H (2003). "Effect of Maitake (Grifola frondosa) D-Fraction on theactivation of NK cells in cancer patients". Journal of Medicinal Food 6(4): 371–7. doi:10.1089/109662003772519949. PMID 14977447.
16) Kodama N, Komuta K,Sakai N, Nanba H (December 2002). "Effects of D-Fraction, a polysaccharidefrom Grifola frondosa on tumor growth involve activation of NK cells".Biological & Pharmaceutical Bulletin 25 (12): 1647–50.doi:10.1248/bpb.25.1647. PMID 12499658.
17) Kodama N, Asakawa A,Inui A, Masuda Y, Nanba H (March 2005). "Enhancement of cytotoxicity of NKcells by D-Fraction, a polysaccharide from Grifola frondosa". OncologyReports 13 (3): 497–502. PMID 15706424.
18) Kodama N, Murata Y,Nanba H (2004). "Administration of a polysaccharide from Grifola frondosastimulates immune function of normal mice". Journal of Medicinal Food 7(2): 141–5. doi:10.1089/1096620041224012. PMID 15298759.
Inaoka Y, Shakuya A,Fukazawa H, Ishida H, Nukaya H, Tsuji K, Kuroda H, Okada M, Fukushima M, Kosuge T: Studies on activesubstances in herbs used for hair treatment. I. Effects of herb extracts on hair growth and isolation of anactive substance from Polyporus umbellatus F. : Chem Pharm Bull (Tokyo).1994 Mar;42(3):530-3.
Ishida H, Inaoka Y,Shibatani J, Fukushima M, Tsuji K: Studies of the active substances in herbsused for hair treatment. II. Isolation of hair regrowth substances,acetosyringone and polyporusterone A andB, from Polyporus umbellatus Fries. Biol Pharm Bull. 1999 Nov;22(11):1189-92.
Li JJ, Tu YY, Tong JZ,Wang PT: Inhibitory activity of Dianthus superbus L. and 11 kinds of diuretic Traditional Chinese medicines forurogenital Chlamydia trachomatis in vitro. Zhongguo Zhong Yao Za Zhi. 2000 Oct;25(10):628-30.
Sekiya N, Hikiami H, Nakai Y, Sakakibara I, Nozaki K, Kouta K, Shimada Y, Terasawa K: Inhibitory effects oftriterpenes isolated from Chuling (Polyporus umbellatus Fries) on free radicalinduced lysis of red blood cells. Biol PharmBull. 2005 May;28(5):817-21.
Yang LJ, Wang RT, Liu JS, Tong H,Deng YQ, Li QH: Theeffect of polyporus umbellatus polysaccharide on the immunosuppression property ofculture supernatant of S 180 cells. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2004Mar;20(2):234-7.
You JS, Hau DM, ChenKT, Huang HF: Combined effects of chuling (Polyporus umbellatus) extract and mitomycin Con experimental liver cancer. Am J Chin Med. 1994;22(1):19-28.
Yuan D, Mori J, Komatsu KI, Makino T, Kano Y: Anantialdosteronic diuretic component (drain dampness) in Polyporus sclerotium. Biol Pharm Bull.2004 Jun;27(6):867-70.
Zhang YH, Liu YL, Yan SC: Effect of Polyporusumbellatus polysaccharide on function of macrophages in the peritoneal cavities of micewith liver lesions. Zhong Xi Yi Jie He Za Zhi. 1991 Apr;11(4):225-6, 198.
Quelle MRC Austria
1) Pharmacology andApplications of Chinese Materia Medica. Chang H.M, But P.P.H. 1986.Singapore:World Scientific
2) Studies on constituentsof fruit body of Polyporus umbellatus and their cytotoxic activity. Ohsawa T,Yukawa M, Takao C, Murayama M, Bando H. Chem Pharm Bull (Tokyo).1992;40(1):143-7
3) Cytotoxic steroids fromPolyporus umbellatus. Zhao Y.Y, Chao X, Zhang Y, Lin R.C, Sun W.J. Planta Med.2010. Epub
4) Simultaneousdetermination of eight major steroids from Polyporus umbellatus byhigh-performance liquid chromatography coupled with mass spectrometrydetections. Zhao Y.Y, Cheng X.L, Zhang Y, Zhao Y, Lin R.C, Sun W.J. BiomedChromatogr. 2010;24(2):222-30.
5) Bioactivity-directedisolation, identification of diuretic compounds from Polyporus umbellatus. ZhaoY.Y, Xie R.M, Chao X, Zhang Y, Lin RC, Sun W.J. J Ethnopharmacol.2009;126(1):184-7.
6) An anti-aldosteronicdiuretic component (drain dampness) in Polyporus sclerotium. Yuan D, et al.Biol Pharm Bull. 2004;27(6):867-70
7) Diuretic activity andkidney medulla AQP1, AQP2, AQP3, V(2)R expression of the aqueous extract ofsclerotia of Polyporus umbellatus FRIES in normal rats. Zhang G, Zeng X, Han L,Wei J.A, Huang H. J Ethnopharmacol. 2010 Epub
8) Recent advances on theactive components in Chinese medicine. Zhu D. Abstracts of Chinese Medicines.1987;1:251-286
9) Review on the studiesof antineoplastic fungal polysaccharides. Li M. Jiangxi Zhongyiyao.1985;63:59-61
10) Chinese MedicalHerbology and Pharmacology. Chen J.K, Chen T.T. 2001:386. Pub. Art of MedicinePress
11) Combined effects ofchuling (Polyporus umbellatus) extract and mitomycin C on experimental livercancer. You J.S, Hau D.M, Chen K.T, Huang H.F. Am J Chin Med. 1994;22(1):19-28.
12) TLR4-mediatedactivation of macrophages by the polysaccharide fraction from Polyporusumbellatus(pers.) Fries. Li X, Xu W. J Ethnopharmacol. 2010 Epub.
13) Polysaccharidepurified from Polyporus umbellatus (Per) Fr induces the activation andmaturation of murine bone-derived dendritic cells via toll-like receptor 4. LiX, Xu W, Chen J. Cell Immunol. 2010;265(1):50-6.
14) Inhibitory effect ofChinese herb medicine zhuling on urinary bladder cancer. An experimental andclinical study. Yang D.A. Zhonghua Wai Ke Za Zhi. 1991;29(6):393-5,399.
15) Prevention ofpostoperative recurrence of bladder cancer: a clinical study. Yang D, Li S,Wang H, Li X, Liu S, Han W, Hao J, Zhang H. Zhonghua Wai Ke Za Zhi. 1999;37(8):464-5.
16) Inhibitive effect ofumbellatus polyporus polysaccharide on cachexic manifestation induced bytoxohormone-L in rats. Wu G.S, Zhang L.Y, Okuda H. Zhongguo Zhong Xi Yi Jie HeZa Zhi. 1997;17(4):232-3.
17) Studies of the activesubstances in herbs used for hair treatment. II. Isolation of hair regrowthsubstances, acetosyringone and polyporusterone A and B, from Polyporusumbellatus Fries. Ishida H, Inaoka Y, Shibatani J, Fukushima M, Tsuji K. BiolPharm Bull. 1999;22(11):1189-92
18) Studies on activesubstances in herbs used for hair treatment. I. Effects of herb extracts onhair growth and isolation of an active substance from Polyporus umbellatus F.,Inaoka Y1, Shakuya A, Fukazawa H, Ishida H, Nukaya H, Tsuji K, Kuroda H, OkadaM, Fukushima M, Kosuge T., Chem Pharm Bull (Tokyo). 1994 Mar;42(3):530-3.